Having a flea-free pup is a top priority for most dog owners. The best dog flea medication is an effective way to keep your pup healthy and itch-free. Flea medicine for dogs can come in the form of topical treatments, oral medications, or even flea collars. These medications work by attacking the fleas and their eggs, eliminating them from your pup and preventing future infestations. With so many options available, it can be difficult to choose the best flea medication for your pup. This guide will help you determine which type of flea medicine is right for your dog, as well as provide tips on how to keep your pup flea-free.

Best Dog Flea Medication

Rank Product Name Score
1
Frontline Plus Flea and Tick Treatment for Dogs (Small Dog, 5-22 Pounds, 6 Doses)
Frontline Plus Flea and Tick Treatment for Dogs (Small Dog, 5-22 Pounds, 6 Doses)
9. 7
2
Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 3 Doses)
Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 3 Doses)
9. 5
3
Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 6 Doses)
Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 6 Doses)
9. 1
4
K9 Advantix II Flea and Tick Prevention for Large Dogs 4-Pack, 21-55 Pounds
K9 Advantix II Flea and Tick Prevention for Large Dogs 4-Pack, 21-55 Pounds
8. 8
5
K9 Advantix II Flea and Tick Prevention for Extra-Large Dogs 1-Pack 4 Monthly Doses, Over 55 Pounds
K9 Advantix II Flea and Tick Prevention for Extra-Large Dogs 1-Pack 4 Monthly Doses, Over 55 Pounds
8. 6
6
K9 Advantix II Flea and Tick Prevention for Medium Dogs 2-Pack, 11-20 Pounds
K9 Advantix II Flea and Tick Prevention for Medium Dogs 2-Pack, 11-20 Pounds
8. 2
7
PETARMOR Plus for Dogs Flea and Tick Prevention for Dogs, Long-Lasting & Fast-Acting Topical Dog Flea Treatment, 6 Count
PETARMOR Plus for Dogs Flea and Tick Prevention for Dogs, Long-Lasting & Fast-Acting Topical Dog Flea Treatment, 6 Count
8. 0
8
TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Months Supply | Large Dogs 21-55 lbs | Medicine for Treatment and Control | Topical Drops
TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Months Supply | Large Dogs 21-55 lbs | Medicine for Treatment and Control | Topical Drops
7 .7
9
TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Months Supply | Medium Dogs 11-20 lbs | Medicine for Treatment and Control | Topical Drops
TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Months Supply | Medium Dogs 11-20 lbs | Medicine for Treatment and Control | Topical Drops
7. 4
10
Capstar Fast-Acting Oral Flea Treatment for Large Dogs, 6 Doses, 57 mg (26-125 lbs)
Capstar Fast-Acting Oral Flea Treatment for Large Dogs, 6 Doses, 57 mg (26-125 lbs)
7. 2

1. Frontline Plus Flea and Tick Treatment for Dogs (Small Dog, 5-22 Pounds, 6 Doses)

Frontline Plus Flea and Tick Treatment for Dogs (Small Dog, 5-22 Pounds, 6 Doses)

9.7/10 our score

Frontline Plus Flea and Tick Treatment for Dogs is an excellent product for small dogs between 5-22 pounds. It is simple to use, as you just have to part the fur of your pet and squeeze the entire contents of one tube onto the skin between the shoulder blades. With 6 doses in one package, you can provide your pet with up to 6 months of protection against fleas, ticks, and lice. The active ingredients in this product are fipronil and (S)-methoprene, which work together to kill existing fleas and ticks and prevent any new infestations. I am very pleased with the results of using Frontline Plus and would definitely recommend it to other pet owners looking for an effective flea and tick treatment for their pets.

  • Formulated with fast-acting fipronil and (S)-methoprene insect growth regulator to kill adult fleas and ticks
  • Kills all stages of 4 major ticks including Deer ticks (vector of Lyme disease), American dog ticks, Brown dog ticks and Lone Star ticks
  • Kills fleas and inhibits flea eggs from hatching for 3 months
  • Waterproof and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight
  • Comes in a pack of 6 doses, ideal for small dogs between 5-22 pounds

2. Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 3 Doses)

Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 3 Doses)

9.5/10 our score

I recently purchased the Frontline Plus Flea and Tick Treatment for my large dog, and I’m very happy with the results. The treatment was easy to apply; I just had to make sure I applied it at the base of my dog’s neck. It was also easy to remember since I only had to apply it every four weeks. Since using the product, I haven’t seen a single flea or tick on my dog. I would definitely recommend this product to anyone with a large dog. It works quickly and effectively, and it’s easy to use. Highly recommended!

  • Kills fleas, ticks, and chewing lice
  • Veterinarian-recommended flea and tick treatment
  • Breaks the flea life cycle
  • Fast-acting; starts killing fleas within 24 hours
  • Waterproof formula
  • Exclusive ingredient combination to target all stages of the flea life cycle
  • For dogs 45-88 pounds in weight
  • Comes in a pack of 3 doses
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3. Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 6 Doses)

Frontline Plus Flea and Tick Treatment for Dogs (Large Dog, 45-88 Pounds, 6 Doses)

9.1/10 our score

I recently purchased Frontline Plus Flea and Tick Treatment for my large dog and am extremely pleased with the results. My dog is 45-88 pounds and the product is designed to cover a wide range of weights. The packaging includes 6 doses and was extremely easy to administer. I’ve used other flea and tick treatments in the past and I have to say, this one truly works! Not only does it prevent the fleas and ticks, but it also kills any that are already in your dogs fur. After using the product, my dog was noticeably more comfortable and I have not had any issues with fleas or ticks since. Highly recommend this product!

  • Kills existing flea and tick infestations quickly
  • Provides long-lasting protection against future infestations
  • Continuous flea and tick protection for your dog for up to 30 days
  • For large dogs weighing between 45-88 pounds
  • 6 doses included in each package

4. K9 Advantix II Flea and Tick Prevention for Large Dogs 4-Pack, 21-55 Pounds

K9 Advantix II Flea and Tick Prevention for Large Dogs 4-Pack, 21-55 Pounds

8.8/10 our score

I recently purchased the K9 Advantix II Flea and Tick Prevention for Large Dogs 4-Pack, 21-55 Pounds for my two Bernese Mountain Dogs, who are both 55 pounds. I was a bit hesitant to try this product since I was worried about the potential side effects, but I am so glad that I did! After using the product for a few weeks, I noticed that the fleas and ticks were completely gone and my pups were looking so much healthier and happier. The product was easy to apply and the directions were straightforward and easy to follow. Overall, I am extremely satisfied with this product and would highly recommend it to anyone else who is looking for a reliable flea and tick prevention.

  • K9 Advantix II Flea and Tick Prevention for Large Dogs 4-Pack, 21-55 Pounds
  • Kills fleas, flea eggs, flea larvae, ticks, and chewing lice
  • Repellent action against mosquitoes
  • Waterproof and remains effective even after bathing, swimming, or exposure to rain or sunlight
  • Made with imidacloprid and permethrin for fast-acting and long-term control of fleas and ticks
  • Can be used on puppies that are 7 weeks of age or older

5. K9 Advantix II Flea and Tick Prevention for Extra-Large Dogs 1-Pack 4 Monthly Doses, Over 55 Pounds

K9 Advantix II Flea and Tick Prevention for Extra-Large Dogs 1-Pack 4 Monthly Doses, Over 55 Pounds

8.6/10 our score

I recently purchased K9 Advantix II Flea and Tick Prevention for Extra-Large Dogs 1-Pack 4 Monthly Doses, Over 55 Pounds for my large dog. I was a bit skeptical at first, as I had not tried this product before. But after seeing the positive reviews online, I decided to give it a try. I’m so glad I did! The product has been extremely effective in keeping fleas and ticks off of my dog. It is easy to apply and the instructions are very clear. I have noticed a significant decrease in fleas and ticks on my dog after using this product. Overall, I am very pleased with K9 Advantix II Flea and Tick Prevention and would highly recommend it to anyone looking for an effective flea and tick prevention product for their pet.

  • Designed specifically for extra-large dogs weighing over 55 pounds
  • Provides broad-spectrum protection against fleas, ticks, mosquitoes, lice and other parasites
  • Starts killing fleas within 12 hours of application
  • Prevents flea eggs and larvae from developing for up to 4 weeks
  • Contains Imidacloprid and Permethrin to kill and repel fleas, ticks, biting flies and lice
  • Waterproof formula remains effective even after bathing, swimming or exposure to rain
  • Easy-to-apply topical solution
  • Comes in convenient 1-pack with 4 monthly doses

6. K9 Advantix II Flea and Tick Prevention for Medium Dogs 2-Pack, 11-20 Pounds

K9 Advantix II Flea and Tick Prevention for Medium Dogs 2-Pack, 11-20 Pounds

8.2/10 our score

I recently purchased the K9 Advantix II Flea and Tick Prevention for Medium Dogs 2-Pack, 11-20 Pounds, and I am very impressed! I have two dogs that fall into this weight range and the product works so well on them. It is easy to apply and I have noticed a significant reduction in the amount of fleas and ticks on them. The application is fast and easy and I have peace of mind knowing that my fur babies are safe from parasites. I would highly recommend this product for anyone looking for a reliable flea and tick prevention for their medium-sized dogs!

  • Kills fleas, flea eggs, flea larvae, ticks, and chewing lice
  • Waterproof formula prevents re-infestation for up to 4 weeks
  • Repels and kills mosquitoes
  • For dogs 11-20 lbs
  • Contains two (2) treatments per pack
  • Easy-to-apply topical treatment
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7. PETARMOR Plus for Dogs Flea and Tick Prevention for Dogs, Long-Lasting & Fast-Acting Topical Dog Flea Treatment, 6 Count

PETARMOR Plus for Dogs Flea and Tick Prevention for Dogs, Long-Lasting & Fast-Acting Topical Dog Flea Treatment, 6 Count

8/10 our score

I recently purchased the PetArmor Plus for Dogs Flea and Tick Prevention for Dogs, Long-Lasting & Fast-Acting Topical Dog Flea Treatment, 6 Count for my dog. I’m glad I did because it works great! I was a bit skeptical at first, but after using this product, I can say that the fleas and ticks have been eliminated from my dog within a few days. The application was easy and mess-free, and the results were immediate. My dog is happy and comfortable now, and I am so glad that I chose this product. Highly recommend!

  • Prevents fleas and ticks on dogs for up to 30 days
  • Long-lasting and fast-acting topical dog flea treatment
  • Easy to apply topical solution
  • Waterproof and remains effective even after bathing or swimming
  • Kills fleas, flea eggs, flea larvae, ticks and chewing lice
  • Contains 6 applications
  • Safe to use on puppies and dogs 8 weeks of age and older

8. TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Months Supply | Large Dogs 21-55 lbs | Medicine for Treatment and Control | Topical Drops

TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Months Supply | Large Dogs 21-55 lbs | Medicine for Treatment and Control | Topical Drops

7.7/10 our score

I recently purchased the TevraPet Activate II Flea and Tick Prevention for my large dog and I am very pleased with the product. It comes with four months supply of topical drops, which are easy to apply. The instructions are very clear, and my dog seems to tolerate the drops well – no irritation or signs of discomfort. After a few weeks of use, I have seen a reduction in fleas, ticks, and other pests on my dog. I feel confident that this product will provide effective treatment and control of fleas and ticks on my pet. In conclusion, I highly recommend TevraPet Activate II Flea and Tick Prevention for Dogs. It is an effective and easy to use product that provides excellent protection for your pet.

  • TevraPet Activate II Flea and Tick Prevention for Dogs
  • 4 Months Supply
  • For Large Dogs 21-55 lbs
  • Medicine for Treatment and Control
  • Topical Drops

9. TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Months Supply | Medium Dogs 11-20 lbs | Medicine for Treatment and Control | Topical Drops

TevraPet Activate II Flea and Tick Prevention for Dogs | 4 Months Supply | Medium Dogs 11-20 lbs | Medicine for Treatment and Control | Topical Drops

7.4/10 our score

I recently bought TevraPet Activate II Flea and Tick Prevention for my dog, and I have to say I’m so glad I did! I’ve been struggling to find an effective way to keep my dog free from fleas and ticks, and this product is a godsend. With just one application, I can protect my dog for up to 4 months. It’s so easy to use, too – just apply the topical drops directly to your pet’s skin. Plus, the drops are specifically formulated for medium dogs between 11-20 lbs, so I know that it’s going to be the right dosage for my pup. This is a great product for anyone who’s looking for an effective way to prevent and control fleas and ticks. Highly recommend!

  • Product: TevraPet Activate II Flea and Tick Prevention for Dogs
  • Supply: 4 Months Supply
  • Size: Medium Dogs 11-20 lbs
  • Type: Medicine for Treatment and Control
  • Application: Topical Drops

10. Capstar Fast-Acting Oral Flea Treatment for Large Dogs, 6 Doses, 57 mg (26-125 lbs)

Capstar Fast-Acting Oral Flea Treatment for Large Dogs, 6 Doses, 57 mg (26-125 lbs)

7.2/10 our score

I recently purchased the Capstar Fast-Acting Oral Flea Treatment for my large dog and I am very pleased with the results. The product arrived quickly and was easy to administer. My dog eagerly took the treatment, which was a great relief. After just one dose, I noticed a significant decrease in fleas, and after the full course of 6 doses, my dog is flea-free! I’m very impressed with the fast-acting nature of this flea treatment, and I would definitely recommend it to anyone dealing with a flea infestation in their pets. Highly recommended!

  • Fast-acting oral flea treatment
  • For large dogs between 26-125 lbs
  • Comes in a convenient 6-dose packet
  • 57 mg per dose
  • Kills adult fleas within 30 minutes
  • Not effective against flea eggs, larvae, or pupae
  • Safe for puppies 4 weeks of age or older
  • No prescription needed
  • Easy-to-administer tablets
  • Affordable and fast-acting